||MSc or PhD positions in Neuropharmacology |
|Qualifications: (detailed) |
We are looking for motivated candidates who hold a B.Sc. in biology or related discipline. They must be interested in neurobiology, have good problem solving skills, and can work independently.
Successful candidates will be admitted to the graduate program through the College of Pharmacy, where they are expected to complete some course work in addition to research experiments. All students will be paid a stipend to cover tuition and living expenses. If the student is successful in the first year of the program, there will be an opportunity to transition directly to the PhD program. International students who are from countries where the primary language is not English – regardless of the language of their instruction – will also require a minimum TOEFL iBT score of 100 out of 120 (equivalent to a TOEFL CBT of 250 out of 300, a TOEFL PBT of 600 out of 677, or an IELTS score of 7.5 out of 9.0).
Please submit a letter with statement of research interests, CV including research experience, transcripts and contact details for 2 references by email.
|Duties and responsibilities: |
We have developed in vivo imaging techniques to simultaneously monitor pericyte calcium and blood flow. The proposed project will employ novel mouse models and these imaging techniques to investigate the effects of pericyte signaling on brain capillary blood flow in vivo. Students will be expected to learn mouse handling, stereotaxic injection of AAVs, in vivo and ex vivo two-photon calcium microscopy, intrinsic optical imaging, histological techniques and computer image analysis.
Students will also be responsible for course work, as outlined in the Pharmacy graduate studies program. Our lab also has regular lab meetings and participates in journal club, so students will be expected to give oral presentations on their work and the work of others in the field. Finally, students will present posters on their work at conferences and actively participate in the writing of abstracts and manuscripts.
Involvement of animals, humans and/or hazards:
||Candidates must be comfortable with mouse experimentation. |
|How to Apply
||2019-02-01 Open until filled |
||Undergraduate, Graduate |
||Email firstname.lastname@example.org |
|Required application materials: |
- Cover letter
- A statement indicating the school, program and year
that you are currently enrolled in.
|| Investigating the role of capillary pericytes in blood flow control |
|Project description: |
Neuronal energy demand during synaptic activity is met by increasing local blood flow, a process which is known as functional hyperemia or neurovascular coupling. Though extensively studied in recent years, the cellular mechanisms controlling functional hyperemia remain unclear. Majority of the field has focussed on interactions between neurons, astrocytes and arterioles, but new evidence suggests that vascular pericytes may regulate cerebral blood flow at the capillary level. Our goal is to learn more about the cellular physiology of pericytes, including their intracellular calcium signaling pathways and how this impacts brain blood flow.
|Researcher/Supervisor: Jillian Stobart |
||Faculty of Pharmacy |
|Number of jobs:
||ASAP to [tbd] |